Anaphylactic or anaphylactoid reactions to neomycin; history of anaphylactic or anaphylactoid reactions. Febrile states; acute infectious diseases, leukaemia, severe anaemia & other severe diseases of the blood system; decompensated heart disease. Following administration of gammaglobulin or blood transfusions. Concomitantly receiving corticosteroids or other immunosuppressive drugs; undergoing RT. Severe renal impairment. Pregnancy.